.
Trial Results


Rifabutin and Macrolide Antibiotic Treatment in Crohn’s Patients Identified Serologically Positive for Mycobacterium avium ss. paratuberculosis

I. Shafran, C. Piromalli, S. A. Naser
Gastroenterology 118(4): A4182 (2000)
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Results 2
Use of Corticosteroids
  Past History  At Start of RMAT  After RMAT
Total (42) 
35 
17 
5 
Responder (27)
22 
11
0 
Partial Responder (3) 
2
1
1
Non-Responder (5)
5
2
2
Withdrawal (7) 
6
3
2

 

Results 3
Stool Culture Results and Bacterial Classification
  Negative  Positive  Classification 
Total (42)
7
2
 Mycobacterium avium complex and
Mycobacterium scotochromogen 
Responder (27) 
5
1
 Mycobacterium scotochromogen 
Partial Responder (3) 
1
0
 None 
Non-Responder (5) 
0
1
 Mycobacterium avium complex 
Withdrawal (7) 
1
0
 None

Results 4
MAP Tissue Culture Results
  Negative (Bx) Positive (Bx) Negative
(Resected Tissue)		 Positive
(Resected Tissue) 
Total (42) 
4
2
1
0
Responder (27) 
3
1
0
0
Partial Responder (3)
0
0
0
0
Non-Responder (5) 
1
1
1
0
Withdrawal (7) 
0
0
0
0

Results 5
Adverse Reactions While on RMAT
Adverse Reactions
Number of Patients
Arthralgia
19
Fatigue
19
Jarisch-Hershiemer like Reaction
13
Increased Diarrhea
8
Suppressed Appetite
8
Nausea
6
Decreased WBC
5
Elevated Liver Enzymes
3
Insomnia
3
Mild skin reactions
3
Yeast Infection
3
Itching of palms and feet
2
Teeth Discoloration
2
Hair Thinning
2
Iritis
1
Numb Hands
1
Thrush
1
No adverse reactions reported
5

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