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Trial Results
Rifabutin and Macrolide Antibiotic Treatment in Crohn’s Patients Identified Serologically Positive for Mycobacterium avium ss. paratuberculosis
I. Shafran, C. Piromalli, S. A. Naser
Gastroenterology 118(4): A4182 (2000)
Page 3:
Results1
| All Patients | Responders | Partial Responders | Non Responders | |
| Total Number (%) | 35/35
(100%) |
27/35
(77.1%) |
3/35
(8.6%) |
5/35
(14.3%) |
| No. of Men/Women | 16/19 | 12/15 | 1/2 | 3/2 |
| Age (yr.)
[Mean (SD)] |
37.3
(14.4) |
36.5
(15.7) |
33.3
(9.5) |
41.6
(16.4) |
| Age Range | 18-72 | 18-72 | 26-44 | 26-64 |
| Duration Of Disease (Months) [Mean (SD)] | 122.1 (124.0) | 122.7 | 95.3
(20.2) |
208.8
(124.9) |
| Duration Of Disease
(Range) |
8-420 | 8-420 | 72-108 | 36-372 |
| Primary Location of Disease | ||||
| Colon | 9 | 6 | 2 | 1 |
| Ileum-Colon | 15 | 12 | 1 | 2 |
| Ileum | 9 | 9 | 0 | 0 |
| Duodenum | 1 | 0 | 0 | 1 |
| Ileum-Colon | 1 | 0 | 0 | 1 |
| Perianal - perirectal disease (%) | 12/35
(34.3%) |
7/27
(20%) |
3/3
(100%) |
2/5
(40%) |
| Perforating Disease (%) | 21/35
(60%) |
14/27
(51.9%) |
3/3
(100%) |
4/5
(80%) |
| Fistula only | 10 | 9 | 0 | 1 |
| Abscess Only | 3 | 1 | 1 | 1 |
| Fistula and ABCs | 8 | 4 | 2 | 2 |
| Previous Resection (%) | 13/35
(37.1) |
10/27
(74) |
1/3
(33.3) |
2/5
(40) |
| Extra gastrointestinal symptoms (%) | 25/35
(71.4) |
20/27
(74) |
2/3
(66.6) |
3/5
(60) |
| Medications at start of treatment | ||||
| None | 7 | 5 | 0 | 2 |
| Corticosteroid & Anti inflamatories | 8 | 6 | 1 | 1 |
| Corticosteroid Only | 6 | 5 | 0 | 1 |
| Anti inflammatory Only | 12 | 9 | 2 | 1 |
| Immunosuppressants & Anti inflammatory | 2 | 2 | 0 | 0 |
| RMAT Duration (months) [Mean (SD)] | 8.5
(5.2) |
7.7
(5.2) |
11.5
(2.2) |
9.4
(5.0) |
| RMAT Duration Range (Months) | 1-22 | 1-22 | 9-13 | 5-17 |
The information contained in this site is intended for information purposes only and is not intended as a means of diagnosing or treating disease. Please consult your doctor before starting any treatment.
